Longitudinal prostate-specific antigen reference ranges: Choosing the underlying model of age-related changes-Reference-Cited by-同舟云学术

Longitudinal prostate-specific antigen reference ranges: Choosing the underlying model of age-related changes

Published:2016-07-11 Issue:5 Volume:25 Page:1875-1891
ISSN:0962-2802
Container-title:Statistical Methods in Medical Research
language:en
Short-container-title:Stat Methods Med Res

Author:

Simpkin Andrew J¹,Metcalfe Chris¹,Martin Richard M¹,Lane J Athene¹,Donovan Jenny L¹,Hamdy Freddie C²,Neal David E³,Tilling Kate¹

Affiliation:

1. School of Social and Community Medicine, University of Bristol, Bristol, UK

2. John Radcliffe Hospital, University of Oxford, Oxford, UK

3. Cambridge Research Institute Cancer Research, Cambridge, UK

Abstract

Serial measurements of prostate-specific antigen (PSA) are used as a biomarker for men diagnosed with prostate cancer following an active monitoring programme. Distinguishing pathological changes from natural age-related changes is not straightforward. Here, we compare four approaches to modelling age-related change in PSA with the aim of developing reference ranges for repeated measures of PSA. A suitable model for PSA reference ranges must satisfy two criteria. First, it must offer an accurate description of the trend of PSA on average and in individuals. Second, it must be able to make accurate predictions about new PSA observations for an individual and about the entire PSA trajectory for a new individual.

Publisher

SAGE Publications

Subject

Health Information Management,Statistics and Probability,Epidemiology

Link

http://journals.sagepub.com/doi/pdf/10.1177/0962280213503928

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