Neuroimaging of the Injured Pediatric Brain: Methods and New Lessons-Reference-Cited by-同舟云学术

Neuroimaging of the Injured Pediatric Brain: Methods and New Lessons

Published:2018-02-28 Issue:6 Volume:24 Page:652-670
ISSN:1073-8584
Container-title:The Neuroscientist
language:en
Short-container-title:Neuroscientist

Author:

Dennis Emily L.¹^ORCID,Babikian Talin²³⁴,Giza Christopher C.³⁴⁵,Thompson Paul M.¹⁶,Asarnow Robert F.²⁴⁵⁷

Affiliation:

1. Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of University Southern California, Marina del Rey, CA, USA

2. Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA, USA

3. UCLA Brain Injury Research Center, Department of Neurosurgery and Division of Pediatric Neurology, Mattel Children’s Hospital, Los Angeles, CA, USA

4. UCLA Steve Tisch BrainSPORT Program, Los Angeles, CA, USA

5. Brain Research Institute, University of California, Los Angeles, CA, USA

6. Departments of Neurology, Pediatrics, Psychiatry, Radiology, Engineering, and Ophthalmology, University of Southern California, Los Angeles, CA, USA

7. Department of Psychology, University of California, Los Angeles, CA, USA

Abstract

Traumatic brain injury (TBI) is a significant public health problem in the United States, especially for children and adolescents. Current epidemiological data estimate over 600,000 patients younger than 20 years are treated for TBI in emergency rooms annually. While many patients experience a full recovery, for others there can be long-lasting cognitive, neurological, psychological, and behavioral disruptions. TBI in youth can disrupt ongoing brain development and create added family stress during a formative period. The neuroimaging methods used to assess brain injury improve each year, providing researchers a more detailed characterization of the injury and recovery process. In this review, we cover current imaging methods used to quantify brain disruption post-injury, including structural magnetic resonance imaging (MRI), diffusion MRI, functional MRI, resting state fMRI, and magnetic resonance spectroscopy (MRS), with brief coverage of other methods, including electroencephalography (EEG), single-photon emission computed tomography (SPECT), and positron emission tomography (PET). We include studies focusing on pediatric moderate-severe TBI from 2 months post-injury and beyond. While the morbidity of pediatric TBI is considerable, continuing advances in imaging methods have the potential to identify new treatment targets that can lead to significant improvements in outcome.

Funder

National Institutes of Health

Publisher

SAGE Publications

Subject

Clinical Neurology,General Neuroscience

Link

http://journals.sagepub.com/doi/pdf/10.1177/1073858418759489

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