Book Review: Iron and Parkinson’s Disease-Reference-Cited by-同舟云学术

Book Review: Iron and Parkinson’s Disease

Published:2002-02 Issue:1 Volume:8 Page:22-32
ISSN:1073-8584
Container-title:The Neuroscientist
language:en
Short-container-title:Neuroscientist

Author:

Wolozin Benjamin¹,Golts Natalie²

Affiliation:

1. Department of Pharmacology Loyola University Medical Center Maywood, Illinois,

2. Department of Pharmacology Loyola University Medical Center Maywood, Illinois

Abstract

Multiple studies implicate iron in the pathophysiology of Parkinson’s disease (PD). In the brains of patients with PD, iron levels are elevated and the levels of iron-binding proteins are abnormal. Iron has been suspected to contribute to PD because Fe(II) is known to promote oxidative damage. Recent studies suggest that an additional mechanism by which iron might contribute to PD is by inducing aggregation of the α-synuclein, which is a protein that accumulates in Lewy bodies in PD.

Publisher

SAGE Publications

Subject

Clinical Neurology,General Neuroscience

Link

http://journals.sagepub.com/doi/pdf/10.1177/107385840200800107

Reference56 articles.

1. Mice Lacking α-Synuclein Display Functional Deficits in the Nigrostriatal Dopamine System

2. Phosphorus magnetic resonance spectroscopy in multiple system atrophy and Parkinson's disease

3. Chronic systemic pesticide exposure reproduces features of Parkinson's disease

4. The CYP2D6B allele is associated with a milder synaptic pathology in Alzheimer's disease

5. Co-association of parkin and α-synuclein

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