Gender-Related Differences in Apoptotic Pathways After Neonatal Cerebral Ischemia

Author:

Renolleau Sylvain1,Fau Sebastien1,Charriaut-Marlangue Christiane2

Affiliation:

1. Université Pierre et Marie Curie–Paris, France, Service de Réanimation Néonatale et Pédiatrique, Hôpital Armand Trousseau, Université Pierre et Marie Curie–Paris, France

2. Université Pierre et Marie Curie–Paris, France,

Abstract

Many central nervous system (CNS) diseases display sexual dimorphism, specifically a predilection for one gender or a gender-dependent response to treatment. Exposure to circulating sex steroids is felt to be a chief contributor to this phenomenon. However, CNS diseases of childhood and of the elderly also demonstrate gender predominance and/or sexual dimorphism response to therapies. In this short update, we provide information concerning one of the most interesting new emerging concepts related to the influence of the sex in the pathogenesis of developmental brain injuries leading to different levels of neuroprotection between genders after cerebral hypoxia-ischemia or ischemia. NEUROSCIENTIST 14(1):46—52, 2008. DOI: 10.1177/1073858407308889

Publisher

SAGE Publications

Subject

Clinical Neurology,General Neuroscience

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