Microglial Dysfunction in Autism Spectrum Disorder-Reference-Cited by-同舟云学术

Microglial Dysfunction in Autism Spectrum Disorder

Published:2024-05-07 Issue: Volume: Page:
ISSN:1073-8584
Container-title:The Neuroscientist
language:en
Short-container-title:Neuroscientist

Author:

Meng Jian¹²,Zhang Lingliang¹²,Zhang Yun-wu¹²^ORCID

Affiliation:

1. Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, School of Medicine, Xiamen University, Xiamen, China

2. Xiamen Key Laboratory of Brain Center, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China

Abstract

Autism spectrum disorder (ASD) is a highly heterogeneous neurodevelopmental disorder with onset in childhood. The molecular mechanisms underlying ASD have not yet been elucidated completely. Evidence has emerged to support a link between microglial dysfunction and the etiology of ASD. This review summarizes current research on microglial dysfunction in neuroinflammation and synaptic pruning, which are associated with altered transcriptomes and autophagy in ASD. Dysbiosis of gut microbiota in ASD and its correlation with microglial dysfunction are also addressed.

Funder

Postdoctoral Fellowship Program of China Postdoctoral Science Foundation

National Natural Science Foundation of China

China Postdoctoral Science Foundation

Publisher

SAGE Publications

Link

https://journals.sagepub.com/doi/pdf/10.1177/10738584241252576

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