Affiliation:
1. Department of Life Sciences, Pohang University of Science and Technology (POSTECH), Pohang, Gyeongbuk, Korea
Abstract
In addition to modulating a number of cognitive functions including reward, punishment, motivation, and salience, dopamine (DA) plays a pivotal role in regulating threat-related emotional memory. Changes in neural circuits of the amygdala nuclei are also critically involved in the acquisition and expression of emotional memory. In this review, we summarize the regulation of amygdala circuits by DA. Specifically, we describe DA signaling in the amygdala, and DA regulation of synaptic transmission and synaptic plasticity of the amygdala neurons. Finally, we discuss a potential contribution of DA-related mechanisms to the pathogenesis of posttraumatic stress disorder.
Funder
National Research Foundation of Korea
Subject
Clinical Neurology,General Neuroscience
Cited by
46 articles.
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