The Role of the p75 Neurotrophin Receptor in Cholinergic Dysfunction in Alzheimer's Disease-Reference-Cited by-同舟云学术

The Role of the p75 Neurotrophin Receptor in Cholinergic Dysfunction in Alzheimer's Disease

Published:2009-05-20 Issue:4 Volume:15 Page:317-323
ISSN:1073-8584
Container-title:The Neuroscientist
language:en
Short-container-title:Neuroscientist

Author:

Coulson E.J.¹,May L.M.²,Sykes A.M.²,Hamlin A.S.²

Affiliation:

1. Queensland Brain Institute, The University of Queensland, Brisbane, Queensland, Australia,

2. Queensland Brain Institute, The University of Queensland, Brisbane, Queensland, Australia

Abstract

Degeneration of basal forebrain cholinergic neurons is a common feature of Alzheimer's disease and is proposed to be an early and key event in the condition's etiology. This review discusses recent findings that strongly link the p75 neurotrophin receptor (p75 NTR) to both cholinergic neuron degeneration and the production of toxic forms of amyloid-beta (Aß), which is found deposited as amyloid plaques in the brains of Alzheimer's disease patients. Although elucidating the underlying molecular mechanisms and the clinical significance of these findings will require further experimentation, a number of possible scenarios and future research directions are presented.

Publisher

SAGE Publications

Subject

Neurology (clinical),General Neuroscience

Link

http://journals.sagepub.com/doi/pdf/10.1177/1073858408331376

Reference49 articles.

1. Alzheimer’s disease and the basal forebrain cholinergic system: relations to β-amyloid peptides, cognition, and treatment strategies

2. The p75 Neurotrophin Receptor Mediates Neuronal Apoptosis and Is Essential for Naturally Occurring Sympathetic Neuron Death

3. Thirty years of Alzheimer's disease genetics: the implications of systematic meta-analyses

4. Acetylcholine: a neurotransmitter for learning and memory?

5. β-Amyloid Plaques in a Model for Sporadic Alzheimer's Disease Based on Transgenic Anti-Nerve Growth Factor Antibodies

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