Home-based, Remotely Supervised, 6-Week tDCS in Patients With Both MCI and Depression: A Randomized Double-Blind Placebo-Controlled Trial

Author:

Kim Jiheon12,Park Seungchan2,Kim Hansol2,Roh Daeyoung12,Kim Do Hoon12ORCID

Affiliation:

1. Department of Psychiatry, Chuncheon Sacred Heart Hospital, Chuncheon, Republic of Korea

2. Mind-Neuromodulation Laboratory, College of Medicine, Hallym University, Chuncheon, Republic of Korea

Abstract

As depressive symptom is considered a prodrome, a risk factor for progression from mild cognitive impairment (MCI) to dementia, improving depressive symptoms should be considered a clinical priority in patients with MCI undergoing transcranial direct current stimulation (tDCS) intervention. We aimed to comprehensively evaluate the efficacy of the home-based and remotely monitored tDCS in patients with both MCI and depression, by integrating cognitive, psychological, and electrophysiological indicators. In a 6-week, randomized, double blind, and sham-controlled study, 37 community-dwelling patients were randomly assigned to either an active or a sham stimulation group, and received 30 home-based sessions of 2 mA tDCS for 30 min with the anode located over the left and cathode over the right dorsolateral prefrontal cortex. We measured depressive symptoms, neurocognitive function, and resting-state electroencephalography. In terms of effects of both depressive symptoms and cognitive functions, active tDCS was not significantly different from sham tDCS. However, compared to sham stimulation, active tDCS decreased and increased the activation of delta and beta frequencies, respectively. Moreover, the increase in beta activity was correlated with the cognitive enhancement only in the active group. It was not possible to reach a definitive conclusion regarding the efficacy of tDCS on depression and cognition in patients with both MCI and depression. Nevertheless, the relationship between the changes of electrophysiology and cognitive performance suggests potential neuroplasticity enhancement implicated in cognitive processes by tDCS.

Funder

Eisai Korea Inc

The National Research Foundation of Korea (NRF) grant funded by the Ministry of Science, ICT, and Future Planning (MSIP), Government of Korea

The ‘R&D Program for Forest Science Technology,’ provided by Korea Forest Service

YBrain Inc.

The Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Government of Korea

Publisher

SAGE Publications

Subject

Neurology (clinical),Neurology,General Medicine

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