Clinical Correlates of Electroencephalographic Patterns in Critically Ill Patients

Abstract

Objective The objective of this study was to determine the frequency and clinical correlates of different electroencephalographic patterns and their association with clinical outcomes in critically ill patients. Subjects and Methods This retrospective cross-sectional study was performed in the Neurology Department of King Fahd Hospital of the University, Kingdom of Saudi Arabia and involved a review and analysis of medical records pertaining to 179 intensive care unit patients who underwent electroencephalography (EEG) in the June to November 2018 period. Results Among the different etiologies, presence of spike and wave or sharp wave (SWs) was associated with encephalitis ( P = .01) and large artery stroke ( P = .01), whereas markedly attenuated EEG activity ( p = .04) and burst suppression ( P = .01) were associated with large artery stroke and hypoxic ischemic encephalopathy (HIE), respectively. Generalized theta activity ( P = .01) was significantly found in patients of septic encephalopathy, while generalized delta activity ( P = .02) and asymmetrical background ( P = .04) were significantly associated with traumatic brain injury. Presence of periodic discharges in EEG was significantly associated with more adverse clinical outcomes ( P = .001), whereas rhythmic delta activity (RDA) ( P = .03), persistent focal slow wave activity ( P = .01), and asymmetric background ( P = .002) were found in patients who were discharged from hospital with sequelae of current illness. Conclusion Certain EEG patterns are associated with particular underlying etiologies like SWs for encephalitis, markedly attenuated EEG activity and burst suppression with large artery stroke and HIE, respectively. Whereas few EEG patterns, including periodic discharges, RDA, persistent focal slow wave activity have some prognostic value in critically ill patients. However, they cannot be used as markers for prognostic assessment of patients without considering other clinical and diagnostic variables. Further larger prospective studies with continuous EEG monitoring with control of confounding factors are needed.