Is Visual Prediction Impaired in Adolescents with Autism spectrum Disorder? Event-Related Potentials in a Cued Visual GO/NOGO Task-Reference-Cited by-同舟云学术

Is Visual Prediction Impaired in Adolescents with Autism spectrum Disorder? Event-Related Potentials in a Cued Visual GO/NOGO Task

Published:2024-01-31 Issue:4 Volume:55 Page:406-416
ISSN:1550-0594
Container-title:Clinical EEG and Neuroscience
language:en
Short-container-title:Clin EEG Neurosci

Author:

Häger Linda A.¹²,Høyland Anne L.³⁴,Kropotov Juri D.⁵⁶,Åsberg Johnels Jakob²⁷,Weidle Benhard⁸⁹,Hollup Stig¹⁰,Gillberg Christopher²,Billstedt Eva²,Ogrim Geir¹²¹⁰^ORCID

Affiliation:

1. Neuropsychiatric Team, Åsebråten Clinic, Østfold Hospital Trust, Fredrikstad, Norway

2. Gillberg Neuropsychiatry Centre, Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden

3. Department of Mental Health, Faculty of Medicine and Health Sciences, Regional Centre for Child and Youth Mental Health and Child Welfare, Norwegian University of Science and Technology, Trondheim, Norway

4. Department of Pediatrics, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway

5. N.P. Bechtereva Institute of the Human Brain, Russian Academy of Science, St. Petersburg, Russia

6. Department of Neuropsychology, Andrzej Frycz Modrzewski Krakow University, Poland

7. Speech and Language Pathology Unit, Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden

8. St. Olavs University Hospital, Trondheim, Norway

9. Regional Centre for Child and Youth Mental Health and Child Welfare, Central Norway

10. Institute of Psychology, Norwegian Institute of Science and Technology (NTNU), Trondheim, Norway

Abstract

Aim: Deviant visual processing has been observed in autism spectrum disorder (ASD), manifesting as decreased P1 and P2 components of visual event-related potentials (ERPs). Alterations have been attributed to a failure of Bayesian inference, characterized by hypo-activation of top-down predictive abilities. To test this hypothesis, we measured the visual negativity (vN) as an ERP index of visual preparation hypothesized to mirror predictive brain activity. Method: ERPs in a cued visual GO/NOGO task in 63 adolescents with ASD (IQ > 70, attention-deficit hyperactivity disorder excluded) were compared with ERPs in a sex- and age-matched group of 60 typically developing (TD) controls. Results: The behavioral variables (omissions, commissions, reaction time, and reaction time variability), as well as ERP components reflecting, among other processes, cognitive control (contingent negative variation, P3 GO, P3 NOGO, N2 NOGO) did not differ between the groups. There were group differences in visually based ERPs. Besides P1 and P2 differences, the vN component differentiated the 2 groups with the highest effect size ( d = 0.74).Conclusion: This ERP study lends support to the hypothesis suggesting that a Bayesian hypo-prediction could underlie unique perceptual experiences in individuals with ASD. This could lead to a predisposition to perceive the world with reduced influence and modulation from contextual cues, prior experiences, and pre-existing expectations.

Funder

Sykehuset Østfold

Publisher

SAGE Publications

Link

https://journals.sagepub.com/doi/pdf/10.1177/15500594241227974

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