Horseshoe Retinal Tear Minutes After Use of a New Pilocarpine Formulation in a Presbyopic, Emmetropic Man

Author:

Eaddy Isabel C.1,Moushmoush Obadah2,Sabbagh Omar3ORCID,Barazi Muhi Dean4,Sabbagh Osama5

Affiliation:

1. Philadelphia College of Osteopathic Medicine, Philadelphia, PA, USA

2. MedStar Georgetown University Hospital, Ophthalmology, Washington, DC, USA

3. West Virginia University, Morgantown, WV, USA

4. Rice University, Houston, TX, USA

5. George Washington University School of Medicine and Health Sciences, Ophthalmology, Washington, DC, USA

Abstract

Purpose: To examine the risks associated with the use of pilocarpine hydrochloride 1.25% ophthalmic solution prescribed for presbyopia. Methods: The adverse ocular events reported after the use of pilocarpine were compared with the symptoms experienced by a 62-year-old presbyopic man shortly after taking pilocarpine. Results: The patient reported symptoms soon after instilling pilocarpine, including eye pain, hazy vision, and floaters. An examination showed a horseshoe retinal tear, vitreous hemorrhage, and posterior vitreous detachment, for which the patient received extensive clinical and surgical management. Conclusions: This case highlights the need for comprehensive eye examinations and patient education about the warning signs of retinal tears or detachments before prescribing pilocarpine for presbyopia. Vigilance regarding the potential rare adverse effects of this new pilocarpine ophthalmic solution is warranted.

Publisher

SAGE Publications

Reference10 articles.

1. Allergan. A phase 3 efficacy study of pilocarpine HCl ophthalmic aolution (AGN-190584) in participants with presbyopia (GEMINI 2). (NCT03857542). 2019. Accessed November 2022. https://classic.clinicaltrials.gov/ct2/show/NCT03857542

2. Side Effects and Ways to Avoid Them

3. Safety and Efficacy of AGN-190584 in Individuals With Presbyopia

4. Medical therapy for glaucoma: A review

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