Objective Criteria for In-vitro Responses in Human Tumor Colony-forming Assays

Abstract

The application of rigorous statistical criteria to the design and analysis of in-vitro assay techniques can lead to more reliable assessments of their utility. The authors demonstrate that an objective criterion for in-vitro drug sensitivity would yield less pronounced false- negative error rates than a fixed-cutoff rule, and would therefore be more suitable for screen ing of putative chemotherapeutic agents. Key words: drug sensitivity testing; objective criteria. (Med Decis Making 8:304-309, 1988)