Gross and Microscopic Findings with a Combination of Jessner Solution Plus 53% Resorcinol Paste in Chemical Peels

Abstract

Introduction: The purpose of this study was to evaluate the clinical and histopathologic response of photoaged skin to a series of combined Jessner solution and 53% resorcinol paste chemical peels. Materials and Methods: Five women aged 40–53 years were treated with 5 peels at weekly intervals. The peels consisted of applying Jessner solution followed by the application of 53% resorcinol paste for 1 minute initially. This was increased according to the patient's tolerance. Pre-, intra-, and posttreatment clinical signs were tabulated. Skin biopsies were taken before treatment and again 3 days after the fifth peel. Results: Both the clinical and histopathologic signs of photoaging were improved by the peels. Side effects and negative sequelae were minimal, consisting of pruritus and desquamation. Discussion: The peels were well tolerated and resulted in improvement of aged skin. The clinical and histopathologic evaluations indicate that the peel process, performed as presented, results in biological changes in the deep papillary to upper reticular dermis.