Silicone Gel Implants Associated with Autoimmune/Connective Tissue Disease

Abstract

The association of silicone implants with autoimmune disease is comprehensively reviewed and four new cases presented. In some instances of reported cases there appears to be a cause-and-effect relationship between silicone gel implants and the onset of autoimmune diseases, although in most cases the disease appears to be more likely the expected occurrence rate in females of this age group. Basic criteria for establishing a possible causative relationship are presented.