Multiple-Dose Plasma Pharmacokinetic and Safety Study of LY450108 and LY451395 (AMPA Receptor Potentiators) and Their Concentration in Cerebrospinal Fluid in Healthy Human Subjects

Author:

Jhee S. S.,Chappell A. S.,Zarotsky V.,Moran S. V.,Rosenthal M.,Kim E.,Chalon S.,Toublanc N.,Brandt J.,Coutant D. E.,Ereshefsky L.

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Reference15 articles.

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4. Nootropic drugs positively modulate alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-sensitive glutamate receptors in neuronal cultures;Copani;J Neurochem,1992

5. 7-Chloro-3-methyl-3-4-dihydro-2H-1,2,4 benzothiadiazine S,S-dioxide (IDRA 21): a benzothiadiazine derivative that enhances cognition by attenuating DLα-amino-2,3-dihydro-5-methyl-3-oxo-4-isoxazolepropanoic acid (AMPA) receptor desensitization;Zivkovic;J Pharmacol Exp Therap,1995

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