Quantitative Evaluation of Pharmacokinetic Inhibition of CYP3A Substrates by Ketoconazole: A Simulation Study

Author:

Zhao Ping,Ragueneau-Majlessi Isabelle,Zhang Lei,Strong John M.,Reynolds Kellie S.,Levy Rene H.,Thummel Kenneth E.,Huang Shiew-Mei

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Reference19 articles.

1. US Food and Drug Administration. Draft guidance: Guidance for Industry Drug Interaction Studies-Study Design, Data Analysis, and Implications for Dosing and Labeling http:www.fda.govcderGuidance6695dft.htm http:www.fda.govcderguidanceindex.htmclinical20pharmacology http:www.fda.govCderdrugdrugInteractionsdefault.htm

2. Drug-drug interactions: study design, data analysis and implications for dosing recommendations;Huang;Clin Pharmacol Ther,2007

3. The need of multiple doses of 400 mg ketoconazole as a precipitant inhibitor of a CYP3A substrate in an in vivo drug-drug interaction study;Oo;J Clin Pharmacol

4. An open label study to determine how different durations of ketoconazole (ket) dosing inhibit cytochrome P450 3A4 (CYP3A4) as assessed by midazolam (MDZ) pharmacokinetics (PK);Friedman;Clin Pharmacol Ther,2008

5. Prolonged jaundice following ketoconazole-induced hepatic injury;Benson;Dig Dis Sci,1988

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