Concentration-QT Relationships Play a Key Role in the Evaluation of Proarrhythmic Risk During Regulatory Review

Author:

Garnett Christin E.,Beasley Nhi,Bhattaram V. Atul,Jadhav Pravi R.,Madabushi Rajanikanth,Stockbridge Norman,Tornøe Christoffe W.,Wang Yaning,Zhu Hao,Gobburu Jogara V.

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Reference28 articles.

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3. Postmarketing reports of QT prolongation and ventricular arrhythmia in association with cisapride and Food and Drug Administration regulatory actions;Wysowski;Am J Gastroenterol,2001

4. Guidance on E14 clinical evaluation of QT/QTc interval prolongation and proarrhythmic potential for non-antiarrhythmic drugs; availability. Notice;International Conference on Harmonisation;Fed Regist,2005

5. Relationship between the pharmacokinetics and pharmacodynamics of procainamide;Galeazzi;Clin Pharmacol Ther.,1976

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