Population Pharmacokinetic/Pharmacodynamic Modeling to Assist Dosing Schedule Selection for Dovitinib

Author:

Wang Xiaofeng1,Kay Andrea1,Anak Oezlem1,Angevin Eric2,Escudier Bernard2,Zhou Wei1,Feng Yilin1,Dugan Margaret1,Schran Horst1

Affiliation:

1. Novartis Pharmaceuticals Corporation; East Hanover, NJ; USA

2. Institute Gustave Roussy; Villejuif; France

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Reference12 articles.

1. Pharmacokinetics and pharmacodynamics of dovitinib from 5 clinical trials and the introduction to the intermittent dosing schedule;Wang;J Clin Pharmacol

2. Circulating protein biomarkers of pharmacodynamic activity of sunitinib in patients with metastatic renal cell carcinoma: modulation of VEGF and VEGF-related proteins;Deprimo;J Transl Med,2007

3. Shi M 2008

4. The pharmacodynamic effect of TKI258 on plasma biomarkers of angiogenesis in patients with AML and advanced melanoma;Shi;ASCO Meeting Abstracts,2008

5. Wang X Anak O Saro J et al. Population PK modeling/simulation to select a dosing schedule in phase II/III trials for a novel TKI agent with time-dependent and nonlinear PK. Paper presented at: Population Approach Group in Europe Annual Meeting; June 23-26

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