Pharmacokinetic and Pharmacodynamic Differences between Ocular and Nasal Instillation of Carteolol on Intraocular Pressure and Heart Rate in Japanese Men with High CYP2D6 Activity

Author:

Ishii Yoko1,Nakamura Koichi2,Matsuki Shunji3,Uemura Naoto2,Muraguchi Ryoko1,Nakagawa Mikiko4,Nakano Shigeyuki2,Nakatsuka Kazuo1

Affiliation:

1. Department of Ophthalmology, University, Hasama‐machi, Oita, Japan.

2. Department of Clinical Pharmacology and Therapeutics, University, Hasama‐machi, Oita, Japan.

3. Department of Obstetrics and Gynecology, University, Hasama‐machi, Oita, Japan.

4. Department of Laboratory Medicine, Oita Medical University, Hasama‐machi, Oita, Japan.

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Reference43 articles.

1. Stimulation of aqueous humor flow by ANF, turbutaline and VIP: effects of timolol;Siv FE Nilsson;Invest Ophthalmol Vis Sci,1990

2. Ion channel activity of ciliary process epithelium vesicles reconstituted into planar bilayers;Cherksey BD;Invest Ophthalmol Vis Sci,1988

3. Adverse Respiratory and Cardiovascular Events Attributed to Timolol Ophthalmic Solution, 1978–1985

4. Avoiding unsuspected respiratory side-effects of topical timolol with cardioselective or sympathomimetic agents

5. Pharmacogenetic explanation for excessive beta‐blockade following timolol eye drops: potential for oral‐ophthalmic drug interaction;Edeki TI;JAMA,1995

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