Thorough QT/QTc Study of Ritonavir-Boosted Saquinavir Following Multiple-Dose Administration of Therapeutic and Supratherapeutic Doses in Healthy Participants

Author:

Zhang Xiaoping,Jordan Paul,Cristea Laura,Salgo Miklos,Farha Rana,Kolis Stanley,Lee Lois S.

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Reference15 articles.

1. Blockade of HERG channels by HIV protease inhibitors;Anson;Lancet,2005

2. Ritonavir 100 mg does not cause QTc prolongation in healthy subjects: a possible role as CYP3A inhibitor in thorough QTc studies;Sarapa;Clin Pharmacol Ther,2008

3. ICH E14: the clinical evaluation of QT/QTc interval prolongation and proarrhythmic potential for non-antiarrhythmic drugs;International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use;Fed Register,2005

4. A randomized, double-blind, positive-controlled, 14-day multiple ascending dose study to investigate the safety, tolerability, and pharmacokinetics of saquinavir boosted with ritonavir in healthy subjects;Lee;Clin Pharmacol Ther,2009

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