Healthy Volunteers’ Perceptions of the Benefits of Their Participation in Phase I Clinical Trials

Author:

Fisher Jill A.1,McManus Lisa12,Wood Megan M.1,Cottingham Marci D.3,Kalbaugh Julianne M.1ORCID,Monahan Torin1,Walker Rebecca L.1

Affiliation:

1. University of North Carolina at Chapel Hill, NC, USA

2. North Carolina State University, Raleigh, NC, USA

3. University of Amsterdam, The Netherlands

Abstract

Other than the financial motivations for enrolling in Phase I trials, research on how healthy volunteers perceive the benefits of their trial participation is scant. Using qualitative interviews conducted with 178 U.S. healthy volunteers enrolled in Phase I trials, we investigated how participants described the benefits of their study involvement, including, but not limited to, the financial compensation, and we analyzed how these perceptions varied based on participants’ sociodemographic characteristics and clinical trial history. We found that participants detailed economic, societal, and noneconomic personal benefits. We also found differences in participants’ perceived benefits based on gender, age, ethnicity, educational attainment, employment status, and number of clinical trials completed. Our study indicates that many healthy volunteers believe they gain more than just the financial compensation when they accept the risks of Phase I participation.

Funder

National Institute of General Medical Sciences

Publisher

SAGE Publications

Subject

Communication,Education,Social Psychology

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