Proliferative and Apoptotic Responses in Cancers With Special Reference To Oral Cancers

Author:

Kamer A.R.1,Krebs L.2,Hoghooghi S.A.2,Liebow C.2

Affiliation:

1. Department of Oral and Maxillofacial Surgery, 112 Squire Hall, School of Dental Medicine, State University of New York at Buffalo, Buffalo, New York, 14214, USA, Oral Biology, School of Dental Medicine, State University of New York at Buffalo, Buffalo, New York, 14214, USA

2. Department of Oral and Maxillofacial Surgery, 112 Squire Hall, School of Dental Medicine, State University of New York at Buffalo, Buffalo, New York, 14214, USA

Abstract

The study of signal transduction pathways for mechanisms of apoptosis and proliferation has significantly advanced our understanding of human cancer, subsequently leading to more effective treatments. Discoveries of growth factors and oncogenes, especially those that function through phosphorylation on tyrosine residues, have greatly benefited our appreciation of the biology of cancer. The regulation of proliferation and apoptosis through phosphorylation via tyrosine kinases and phosphatases is discussed, as well as the contributions of other systems, such as serine and threonine kinases and phosphatases. Receptors with seven-transmembrane domains, steroid hormones, genes, and "death domains" will also be discussed. This review attempts to compare the regulation of the growth of normal tissues and cancers with an effort to highlight the current knowledge of these factors in the growth regulation of oral/oropharyngeal cancers. Despite the strides made in our understanding of growth regulation in human cancers, the study of oral/oropharyngeal cancer specifically lags behind. More research must be done to further our understanding of oral cancer biology, if we are to develop better, more effective treatment protocols.

Publisher

SAGE Publications

Subject

General Dentistry,Otorhinolaryngology

Reference192 articles.

1. Scanning Tunneling Microscopy of recA-DNA Complexes Coated with a Conducting Film

2. Arends MJ, Wyllie AH (1991). Apoptosis: mechanisms and roles in pathology. lnt Rev Exp Pathol 52:223-254.

3. Armstrong DK, Kaufmann SH, Ottaviano YL, Furuya Y., Buckley JA, Issacs JT, et al. (1994). Epidermal growth factor mediated apoptosis of MDA-MB-468 human breast cancer cells. Cancer Res 54:5280-5283.

4. Baker SJ, Reddy EP (1996). Transducers of life and death: TNF receptor superfamily and associated proteins. Oncogene 12:1-9.

5. Suppression of Human Colorectal Carcinoma Cell Growth by Wild-Type p53

Cited by 16 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3