Affiliation:
1. Department of Medicine, Division of Hematology, University of Texas Health Science Center and the Audie L. Murphy Memorial Veterans Hospital, Research Service, San Antonio, Texas
Abstract
The osteoclast is the primary bone resorbing cell. It is a highly specialized multinucleated cell whose primary function is to help in the control of calcium homeostasis. The osteoclast has been very difficult to study because of its relative inaccessability, low numbers, and fragility when isolated from bone. Recently, techniques have been developed to study the cell biology of the osteoclast that have expanded our ability to understand the biological and functional properties of osteoclasts. In this article, studies on the origin of the osteoclast are reviewed and the differentiation markers that are used to detect cells in the osteoclast lineage are discussed. Factors that affect osteoclast differentiation are presented and model systems currently in use for studying osteoclast differentiation are evaluated for their relative strengths and weaknesses. In addition, osteoclast differentiation during tooth eruption and root resorption and the effects of bone matrix elements on osteoclast differentation are reviewed.
Subject
General Dentistry,Otorhinolaryngology
Reference155 articles.
1. Holtrop, M.E. and King, G.J., The ultrastructure of the osteoclast and its functional implications, Clin. Ortho., 123, 177, 1977.
2. Congenital Osteopetrosis in Mice Cured by Parabiotic Union with Normal Siblings
3. Osteopetrosis Cured by Temporary Parabiosis
4. Gothlin, G. and Ericsson, J.L.E., On the histogenesis of the cells in fracture callus. Electron microscopic and autoradiographic observations in parabiotic rats and studies on labeled monocytes, Virchows Arch. B Cell Pathol., 12, 318, 1973.
5. Observations on the mode of uptake of thorium dioxide particles by osteoclasts in fracture callus
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