Squamous Metaplasia of the Middle Ear Mucosa During Vitamin a Deprivation-Reference-Cited by-同舟云学术

Squamous Metaplasia of the Middle Ear Mucosa During Vitamin a Deprivation

Published:1979-11 Issue:6 Volume:87 Page:837-844
ISSN:0194-5998
Container-title:Otolaryngology–Head and Neck Surgery
language:en
Short-container-title:Otolaryngol Head Neck Surg

Author:

Chole Richard A.¹

Affiliation:

1. Department of Otorhinolaryngology, University of California, Davis, Medical Center, Sacramento, California.

Abstract

Adult and juvenile albino rats were maintained on a vitamin A-free test diet for 2 to 28 weeks. Histologic study of the middle ear and eustachian tube mucosa of these animals showed extensive focal squamous metaplasia when compared with the control group. Keratinization of large areas of normally columnar, ciliated epithelium was observed without frank keratoma formation. In over half of the most vitamin A-deficient animals, acute otitis media with effusion was found. It is hypothesized that vitamin A deficiency disrupts the mucociliary clearing mechanism in the middle ear and eustachian tube, which may lead to effusion and otitis media.

Publisher

SAGE Publications

Subject

Otorhinolaryngology,Surgery

Link

http://journals.sagepub.com/doi/pdf/10.1177/019459987908700618

Reference16 articles.

1. TISSUE CHANGES FOLLOWING DEPRIVATION OF FAT-SOLUBLE A VITAMIN

2. Effects of Tobacco on the Ear

3. Cholesteatosis of the Attic

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