Immunoglobulin a Antibody to Epstein-Barr Viral Antigens and Prognosis in Nasopharyngeal Carcinoma-Reference-Cited by-同舟云学术

Immunoglobulin a Antibody to Epstein-Barr Viral Antigens and Prognosis in Nasopharyngeal Carcinoma

Published:1980-01 Issue:1 Volume:88 Page:52-57
ISSN:0194-5998
Container-title:Otolaryngology–Head and Neck Surgery
language:en
Short-container-title:Otolaryngol Head Neck Surg

Author:

Mathew Gregory D.¹,Qualtiere Louis F.²,Neel H. Bryan¹,Pearson Gary R.²

Affiliation:

1. Departments of otorhinolaryngology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota

2. Departments of cell biology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota

Abstract

IgA immunoglobulin fractions containing antibodies to Epstein-Barr virus (EBV)-induced membrane antigens were isolated from the sera of two patients with nasopharyngeal carcinoma (NPC), from one non-NPC patient, and from three persons with sera negative for IgA antibodies. IgA antibodies were not cytotoxic against cells expressing EBV-induced membrane antigens in the antibody-dependent cellular cytotoxicity (ADCC) assay. However, IgA antibodies blocked IgG-mediated ADCC, which indicated that these antibodies could serve as a blocking “factor” in patients with disease and, therefore, were potentially detrimental to the host.

Publisher

SAGE Publications

Subject

Otorhinolaryngology,Surgery

Link

http://journals.sagepub.com/doi/pdf/10.1177/019459988008800115

Reference13 articles.

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3. Elevated IgA in carcinoma of the nasopharynx

4. Epstein-barr virus-specific IgA serum antibodies as an outstanding feature of nasopharyngeal carcinoma

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