The Effect of Surfactant on Eustachian Tube Function in a Gerbil Model of Otitis Media with Effusion-Reference-Cited by-同舟云学术

The Effect of Surfactant on Eustachian Tube Function in a Gerbil Model of Otitis Media with Effusion

Published:1994-01 Issue:1 Volume:110 Page:110-114
ISSN:0194-5998
Container-title:Otolaryngology–Head and Neck Surgery
language:en
Short-container-title:Otolaryngol Head Neck Surg

Author:

Schwartz Ilsa,Fornadley John A.¹,Burns J. Kevin²

Affiliation:

1. Division of Otolaryngology-Head and Neck Surgery, Naval Hospital, Portsmouth.

2. Department of Surgery, The Pennsylvania State University College of Medicine, The Milton S. Hershey Medical Center, and the Naval Hospital, Portsmouth.

Abstract

The relationship of eustachian tube surfactant and otitis media with effusion on eustachian tube opening pressure was studied in a gerbil model. Injection of killed Streptococcus pneumoniae bacteria created a serous effusion that increased eustachian tube opening pressure. The introduction of exogenous surfactant to this system resulted in a dramatic decrease in eustachian tube opening pressure in both normal ears and those with effusion. Identifying means to increase surfactant in the eustachian tube could be beneficial in reducing persistent otitis media with effusion.

Publisher

SAGE Publications

Subject

Otorhinolaryngology,Surgery

Link

http://journals.sagepub.com/doi/pdf/10.1177/019459989411000113

Reference13 articles.

1. Allergic Factors in Management of Middle Ear Effusions

2. Daniels F., Alberty R. Physical chemistry, ed 4. New York: John Wiley & Sons, 1975: 252.

3. Neue Auffassungen über einen Grundbegriff der Atemmechanik

4. Surface-Active Substances of the Guinea Pig Tubotympanum: A Chemical and Physical Analysis

5. The Valve and “Locking” Mechanisms of the Eustachian Tube