Panel 3: Genetics and Precision Medicine of Otitis Media-Reference-Cited by-同舟云学术

Panel 3: Genetics and Precision Medicine of Otitis Media

Published:2017-04 Issue:4_suppl Volume:156 Page:S41-S50
ISSN:0194-5998
Container-title:Otolaryngology–Head and Neck Surgery
language:en
Short-container-title:Otolaryngol Head Neck Surg

Author:

Lin Jizhen¹,Hafrén Hena²,Kerschner Joseph³,Li Jian-Dong⁴,Brown Steve⁵,Zheng Qing Y.⁶,Preciado Diego⁷,Nakamura Yoshihisa⁸,Huang Qiuhong⁹,Zhang Yan¹⁰

Affiliation:

1. Department of Otolaryngology–Head and Neck Surgery, University of Minnesota, Minneapolis, Minnesota, USA

2. Departments of Otorhinolaryngology–Head and Neck Surgery, Helsinki University Hospital, Helsinki, Finland

3. Department of Otorhinolaryngology and Communication Sciences, Medical College of Wisconsin, Milwaukee, Wisconsin, USA

4. Center for Inflammation, Immunity and Infection, Institute for Biomedical Sciences, Georgia State University, Atlanta, Georgia, USA

5. Medical Research Council Harwell Institute, Oxfordshire, UK

6. Department of Otolaryngology–Head and Neck Surgery, Case Western University, Cleveland, Ohio, USA

7. Shiekh Zayed Institute for Pediatric Surgical Innovation, Pediatric Otolaryngology, Children’s National Health System, Washington, DC, USA

8. Department of Otolaryngology, Nagoya City University, Nagoya, Japan

9. Department of Otolaryngology, Sun Yat-sen University, Guangzhou, China

10. Department of Otolaryngology, Second Affiliated Hospital, Xi’an Jiaotong University, Xi’an, China

Abstract

Objective The objective is to perform a comprehensive review of the literature up to 2015 on the genetics and precision medicine relevant to otitis media. Data Sources PubMed database of the National Library of Medicine. Review Methods Two subpanels were formed comprising experts in the genetics and precision medicine of otitis media. Each of the panels reviewed the literature in their respective fields and wrote draft reviews. The reviews were shared with all panel members, and a merged draft was created. The entire panel met at the 18th International Symposium on Recent Advances in Otitis Media in June 2015 and discussed the review and refined the content. A final draft was made, circulated, and approved by the panel members. Conclusion Many genes relevant to otitis media have been identified in the last 4 years in advancing our knowledge regarding the predisposition of the middle ear mucosa to commensals and pathogens. Advances include mutant animal models and clinical studies. Many signaling pathways are involved in the predisposition of otitis media. Implications for Practice New knowledge on the genetic background relevant to otitis media forms a basis of novel potential interventions, including potential new ways to treat otitis media.

Publisher

SAGE Publications

Subject

Otorhinolaryngology,Surgery

Link

http://journals.sagepub.com/doi/pdf/10.1177/0194599816685559

Reference87 articles.

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