A Cytokine-Delivering Polymer Is Effective in Reducing Tumor Burden in a Head and Neck Squamous Cell Carcinoma Murine Model-Reference-Cited by-同舟云学术

A Cytokine-Delivering Polymer Is Effective in Reducing Tumor Burden in a Head and Neck Squamous Cell Carcinoma Murine Model

Published:2014-05-13 Issue:3 Volume:151 Page:447-453
ISSN:0194-5998
Container-title:Otolaryngology–Head and Neck Surgery
language:en
Short-container-title:Otolaryngol Head Neck Surg

Author:

Lin Yuan¹²³,Luo Jie¹²³,Zhu Weichao Eric⁴,Srivastava Minu³⁵,Schaue Dorthe⁶,Elashoff David A.⁷⁸,Dubinett Steven M.³⁵⁷,Sharma Sherven³⁵,Wu Benjamin⁴⁹¹⁰¹¹,St. John Maie A.¹²⁷

Affiliation:

1. Department of Head and Neck Surgery, University of California, Los Angeles, Los Angeles, California, USA

2. UCLA Head and Neck Cancer Program, University of California, Los Angeles, Los Angeles, California, USA

3. Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California, Los Angeles, Los Angeles, California, USA

4. Department of Bioengineering, University of California, Los Angeles, Los Angeles, California, USA

5. Veterans’ Affairs Greater Los Angeles Healthcare System, Los Angeles, California, USA

6. Department of Radiation Oncology, University of California, Los Angeles, Los Angeles, California, USA

7. Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, California, USA

8. Department of Biostatistics, University of California, Los Angeles, Los Angeles, California, USA

9. Division of Advanced Prosthodontics, Biomaterials, and Hospital Dentistry, University of California, Los Angeles, Los Angeles, California, USA

10. Department of Materials Science and Engineering, University of California, Los Angeles, Los Angeles, California, USA

11. Department of Orthopedic Surgery, David Geffen School of Medicine at UCLA, Los Angeles, California, USA

Abstract

Objective This study aimed to evaluate the therapeutic efficacy of a novel polymer platform delivering cisplatin and cytokines in the treatment of head and neck squamous cell carcinoma (HNSCC). Study Design In vivo study. Setting Academic research laboratory. Subjects and Methods Mice were randomized to receive implantation of (1) no polymer, (2) plain polymer, (3) plain polymer with local cisplatin injection, or (4) cisplatin polymer. The 2 groups of mice implanted with cisplatin polymer or no polymer were further randomized to receive (1) 4 Grays external beam radiation for 4 days or (2) no radiation. For cytokine studies, mice were grouped into (1) no polymer, (2) plain polymer, (3) plain polymer with intratumoral injection of recombinant CCL21 twice a week, (4) polymer containing parental dendritic cells, or (5) polymer containing dendritic cells secreting CCL21 (DC-CCL21). Results The cisplatin-secreting polymer effectively reduced tumors in the mice by more than 16-fold ( P < .01). We also observed a statistically significant lower tumor weight among mice treated with cisplatin polymer and concomitant radiation compared to control groups. The DC-CCL21 polymer reduced SCCVII/SF tumors in the C3H/HeJ mice by more than 41% ( P < .01). Conclusion Herein, we demonstrate the efficacy of a novel polymer platform in delivering cisplatin and cytokines. We also demonstrate that we can effectively grow dendritic cells in the polymer that can actively secrete CCL21 for a minimum of 5 days. This polymer may represent a new therapeutic modality for patients with HNSCC. Once this polymer platform is optimized, we will plan to pursue prospective trials in patients with HNSCC.

Publisher

SAGE Publications

Subject

Otorhinolaryngology,Surgery

Link

http://journals.sagepub.com/doi/pdf/10.1177/0194599814533775

Reference35 articles.

1. Candidate's Thesis: Polymer Chemotherapy for Head and Neck Cancer

2. Microsurgical Free Flap Reconstruction Outcomes in Head and Neck Cancer Patients after Surgical Extirpation and Intraoperative Brachytherapy

3. Combination Nonviral Murine Interleukin 2 and Interleukin 12 Gene Therapy and Radiotherapy for Head and Neck Squamous Cell Carcinoma

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