Seventh Nerve Spasm: Effect of Modification of Cholinergic Balance-Reference-Cited by-同舟云学术

Seventh Nerve Spasm: Effect of Modification of Cholinergic Balance

Published:1980-07 Issue:4 Volume:88 Page:491-499
ISSN:0194-5998
Container-title:Otolaryngology–Head and Neck Surgery
language:en
Short-container-title:Otolaryngol Head Neck Surg

Author:

Hughes Everett C.¹,Brackmann Derald E.²,Weinstein Roy C.¹

Affiliation:

1. Department of Otolaryngology, Los Angeles County-USC Medical Center, Los Angeles, California

2. Department of Otolaryngology, Los Angeles County-USC Medical Center, Far Research Institute, Los Angeles, California

Abstract

The seventh cranial nerve spasms of the face and the eyelids, including essential blepharospasm, are usually intractable and sometimes disabling. Deanol acetamidobenzoate was compared with the anticholinergic orphenadrine for relief of these spasms. Deanol cured two of 16 (12%) subjects and improved a third. Orphenadrine was much more effective, improving the conditions of 16 of 26 (62%) subjects between 57% and 100%. A crossover double-blind experiment showed high significance over a placebo.

Publisher

SAGE Publications

Subject

Otorhinolaryngology,Surgery

Link

http://journals.sagepub.com/doi/pdf/10.1177/019459988008800431

Reference15 articles.

1. HEMIFACIAL SPASM

2. Etiology and definitive microsurgical treatment of hemifacial spasm

3. Blepharospasm: Organic or functional?

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