Dynamic Optical Contrast Imaging: A Technique to Differentiate Parathyroid Tissue from Surrounding Tissues-Reference-Cited by-同舟云学术

Dynamic Optical Contrast Imaging: A Technique to Differentiate Parathyroid Tissue from Surrounding Tissues

Published:2017-01-24 Issue:3 Volume:156 Page:480-483
ISSN:0194-5998
Container-title:Otolaryngology–Head and Neck Surgery
language:en
Short-container-title:Otolaryngol Head Neck Surg

Author:

Kim Irene A.¹²,Taylor Zachary D.²³⁴,Cheng Harrison³,Sebastian Christine¹²,Maccabi Ashkan³,Garritano James³,Tajudeen Bobby¹²,Razfar Ali¹²,Palma Diaz Fernando⁵,Yeh Michael⁴,Stafsudd Oscar⁶,Grundfest Warren³⁴⁶,St. John Maie¹²⁷

Affiliation:

1. Department of Head and Neck Surgery, David Geffen School of Medicine, University of California–Los Angeles, Los Angeles, California, USA

2. Head and Neck Cancer Program, David Geffen School of Medicine, University of California–Los Angeles, Los Angeles, California, USA

3. Department of Bioengineering, Henry Samueli School of Engineering and Applied Sciences, University of California–Los Angeles, Los Angeles, California, USA

4. Department of Surgery, David Geffen School of Medicine, University of California–Los Angeles, Los Angeles, California, USA

5. Department of Pathology, David Geffen School of Medicine, University of California–Los Angeles, Los Angeles, California, USA

6. Department of Electrical Engineering, Henry Samueli School of Engineering and Applied Sciences, University of California–Los Angeles, Los Angeles, California, USA

7. Jonsson Comprehensive Cancer Center, David Geffen School of Medicine, University of California–Los Angeles, Los Angeles, California, USA

Abstract

The variable location and indistinct features of parathyroid glands can make their intraoperative identification challenging. Currently, there exists no routine use of localization methods during surgery. Dynamic optical contrast imaging (DOCI) leverages a novel realization of temporally dependent measurements of tissue autofluorescence that allows the acquisition of specific tissue properties. A prospective series of patients with primary hyperparathyroidism was examined. Parathyroid lesions and surrounding tissues were collected; fluorescence decay images were acquired via DOCI. Ex vivo samples (81 patients) were processed for histologic assessment. DOCI extracts relative fluorescence decay information in a surgically relevant field of view with a clinically accessible acquisition time <2 minutes. Analysis of DOCI revealed microscopic characterization sufficient for tissue type identification consistent with histology ( P < .05). DOCI is capable of efficiently distinguishing parathyroid tissue from adjacent tissues. Such an intraoperative tool would be transformative, helping surgeons to identify lesions, preserve healthy tissue, and improve patient outcomes.

Publisher

SAGE Publications

Subject

Otorhinolaryngology,Surgery

Link

http://journals.sagepub.com/doi/pdf/10.1177/0194599816686294

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