Gender issues of antibody-mediated diseases in neurology: (NMOSD/autoimmune encephalitis/MG)

Author:

Altintas Ayse1,Dargvainiene Justina2,Schneider-Gold Christiane3,Asgari Nasrin4,Ayzenberg Ilya56,Ciplea Andrea I.57,Junker Ralf8,Leypoldt Frank89,Wandinger Klaus-Peter810,Hellwig Kerstin11ORCID

Affiliation:

1. Department of Neurology, School of Medicine, Koc University, Istanbul, Turkey

2. Institute of Clinical Chemistry, University Hospital Schleswig-Holstein, Kiel, Schleswig-Holstein, Germany

3. Department of Neurology, St. Josef Hospital, Ruhr-University Bochum, Bochum, Germany

4. Department of Neurology, University of Southern Denmark, Odense, Syddanmark, Denmark

5. Department of Neurology, St. Josef Hospital Bochum, Ruhr University of Bochum, Germany

6. Department of Neurology, Sechenov First Moscow State Medical University, Moscow, Russia

7. Institute of Clinical Pharmacy and Pharmacotherapy, Heinrich-Heine-University, Düsseldorf, Germany

8. Institute of Clinical Chemistry, University Hospital Schleswig-Holstein, Schleswig-Holstein, Germany

9. Department of Neurology, University Hospital Schleswig-Holstein, Campus Kiel, Schleswig-Holstein, Germany

10. Department of Neurology, University Hospital Schleswig-Holstein, Campus Lübeck

11. Department of Neurology, St. Josef Hospital Bochum, Ruhr University of Bochum, Gudrunstrasse 56, Bochum, 44791, Germany

Abstract

Neuromyelitis optica spectrum disorder (NMOSD), autoimmune encephalitis (AE), myasthenia gravis (MG) and Lambert-Eaton myasthenic syndrome (LEMS) are antibody-mediated neurological diseases. They have mostly female predominance, affecting many women during childbearing age. Interactions between the underlying disease (or necessary treatment) and pregnancy can occur in every of these illnesses. Herein, we present the characteristics of NMOSD, AE, MG and LEMS in general, and review published data regarding the influence of the different diseases on fertility, pregnancy, puerperium, treatment strategy during pregnancy and post-partum period, and menopause but also male factors. We summarise key elements that should be borne in mind when confronted with such cases.

Funder

German Ministry of Education and Research

Publisher

SAGE Publications

Subject

Clinical Neurology,Neurology,Pharmacology

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