Effects of different stent size selection on pipeline embolization device treatment of intracranial aneurysms

Author:

Tong Xin1ORCID,Han Mingyang2,Wu Zhongxue1,Feng Xin34,Liu Aihua56ORCID

Affiliation:

1. Neurointerventional Center, Beijing Neurosurgical Institute and Beijing Tiantan Hospital, Capital University, Beijing, China

2. Department of Neurosurgery, The Third Xiangya Hospital, Central South University, Changsha, China

3. Neurosurgery Center, Department of Cerebrovascular Surgery, Engineering Technology Research Center of Education Ministry of China on Diagnosis and Treatment of Cerebrovascular Disease, Zhujiang Hospital, Southern Medical University, Guangzhou 510280, China

4. Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Guangzhou, China

5. Department of Neuro-intervention, Beijing Neurosurgical Institute and Beijing Tiantan Hospital, Capital University, Beijing, China

6. Neurointerventional Center, Beijing Neurosurgical Institute and Beijing Tiantan Hospital, Capital University, Beijing 100070, China

Abstract

Background: Pipeline embolization device (PED) is becoming increasingly common in therapeutic practice. In idealized model studies, treatment effectiveness may vary with different stent sizes in the same vasculature. The true effect of stent size selection in the clinical setting remains unknown, however. Objective: To determine the true effect of stent size selection in the clinical setting. Design: It is a retrospective review. Methods: A retrospective review was conducted on consecutive patients with aneurysms treated with a PED at our institution. The primary exposures were the difference between the diameter of the stent and the parent artery (DD) and the difference between the length of the stent and the aneurysm neck (DL). The outcomes were the clinical and angiographic results, perioperative complications, balloon application, and in-stent stenosis. The results were generated using univariable and multivariable logistic regression and restricted cubic spline (RCS) curves. Results: A larger DD was significantly associated with incomplete occlusion [odds ratio (OR) = 2.37; 95% confidence interval (CI) = 1.43–3.98; p < 0.001], while a larger DL was significantly associated with balloon application (OR = 1.12; 95% CI = 1.02–1.23; p = 0.021) and in-stent stenosis (>25%) (OR = 1.07; 95% CI = 1.01–1.16; p = 0.042). The RCS curve indicated that the risk of incomplete occlusion increased as the DD became larger, the possibility of balloon application increased as the DL increased when the DL was >5.7 mm, and the risk of in-stent stenosis (>25%) increased as the DL increased. Conclusion: In the clinical setting, stent selection was associated with treatment effectiveness and may add to the treatment burden. These occurrences should be considered for aneurysms treated with PED.

Funder

BTH Coordinated Development-Beijing Science and Technology Planning Project

Research and Promotion Program of Appropriate Techniques for Intervention of Chinese High-risk Stroke People

Natural Science Foundation of China

Beijing Municipal Administration of Hospitals’ Ascent Plan

Beijing Natural Science Foundation

Publisher

SAGE Publications

Subject

Neurology (clinical),Neurology,Pharmacology

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3