Physical properties and cytotoxicity of surface-modified bovine bone-based hydroxyapatite/poly(lactic acid) composites-Reference-Cited by-同舟云学术

Physical properties and cytotoxicity of surface-modified bovine bone-based hydroxyapatite/poly(lactic acid) composites

Published:2010-12-20 Issue:12 Volume:45 Page:1259-1269
ISSN:0021-9983
Container-title:Journal of Composite Materials
language:en
Short-container-title:Journal of Composite Materials

Author:

Rakmae Suriyan¹,Ruksakulpiwat Yupaporn¹,Sutapun Wimonlak¹,Suppakarn Nitinat²

Affiliation:

1. School of Polymer Engineering, Suranaree University of Technology, Nakhon Ratchasima 30000, Thailand, Center of Excellence for Petroleum, Petrochemical and Advanced Materials, Chulalongkorn University, Bangkok 10330, Thailand

2. School of Polymer Engineering, Suranaree University of Technology, Nakhon Ratchasima 30000, Thailand, Center of Excellence for Petroleum, Petrochemical and Advanced Materials, Chulalongkorn University, Bangkok 10330, Thailand,

Abstract

This study was a preliminary observation for a potential use of the bovine bone-based hydroxyapatite (b-HA)/poly(lactic acid) (PLA) composite as a biomaterial. SEM micrographs, XRD pattern, and FTIR spectrum of calcined bovine bone revealed that the obtained powder was in a form of crystalline carbonated HA, and highly agglomerated. The surface of HA powder was modified with either 3-aminopropyltriethoxysilane (APES) or 3-methacryloxypropyltrimethoxysilane (MPTS) in order to enhance the compatibility between b-HA and PLA matrix. TGA and GPC results revealed that the incorporation of silane-treated HA into the PLA matrix significantly increased thermal stability of the composites and decreased the thermal degradation of PLA chains. SEM micrographs revealed that modification of HA with APES or MPTS eased dispersion of HA in PLA matrix and enhanced interfacial adhesion between both phases. Therefore, the mechanical properties of silane treated HA/PLA composites were improved as compared with those of b-HA/PLA composites. In addition, in vitro cytotoxicity tests indicated that the extracts from all HA/PLA composites had no toxicity to human osteoblast cell.

Publisher

SAGE Publications

Subject

Materials Chemistry,Mechanical Engineering,Mechanics of Materials,Ceramics and Composites

Link

http://journals.sagepub.com/doi/pdf/10.1177/0021998310377934

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