Affiliation:
1. Department of Body Composition and Metabolism, Vita Stråket 15, Sahlgrenska University Hospital, 413 45 Göteborg, Sweden,
Abstract
This article reviews the evidence, from both observational epidemiology and randomised clinical trials, that lifestyle modification as well as anti-diabetic drugs can reduce or delay the development of diabetes in overweight and obese patients with IGT. Particular consideration is given to the recently published XENDOS study which showed that the combination of orlistat and lifestyle changes over four years is safe and well tolerated, results in a weight loss of about six kg and reduces the risk of developing diabetes by 45% in obese IGT patients. Thus, addition of orlistat to lifestyle intervention has a greater diabetes-preventing effect than lifestyle modification alone.
Subject
Cardiology and Cardiovascular Medicine,Endocrinology, Diabetes and Metabolism,Internal Medicine
Reference41 articles.
1. Powers AC Diabetes mellitus. In: Braunwald E , Fauci AS, Kasper DL, Hauser SL, Longo DL, Jameson JL eds. Harrison's principles of internal medicine 1 5th edition. New York: McGraw-Hill, 2001:2109-37.
2. Prevention of Type II diabetes in subjects with impaired glucose tolerance: the Diabetes Prevention Study (DPS) in Finland
3. Global and societal implications of the diabetes epidemic
Cited by
2 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献