Transient hyperammonaemia following epileptic seizures in cats

Author:

Nilsson Charlotta H1ORCID,Svensson Mikael BT2,Säve Susanne JM3,Van Meervenne Sofie AE1

Affiliation:

1. Anicura Kalmar Animal Clinic, Kalmar, Sweden

2. Öresunds Veterinary Clinc, Lund, Sweden

3. Anicura Läckeby Animal Hospital, Kalmar, Sweden

Abstract

Objectives The aim of this study was to determine whether transient postictal hyperammonaemia exists in cats. Methods The medical records of all feline patients that presented at a Swedish veterinary hospital between 2008 and 2018 were retrospectively reviewed to find those that had a recent or ongoing epileptic seizure. To qualify for inclusion, the medical record had to include information on at least one ammonia value taken in close proximity to, or during, an active seizure, the cat must have exceeded the normal upper limit of blood ammonia concentration on initial testing (reference interval 0–95 μmol/l), and there needed to be a follow-up ammonia value available within a maximum of 3 days. Results Five cats were included in the study, and they had blood ammonia concentrations on initial testing ranging from 146 to 195 µmol/l. They were all retested within a period of 2 h to 3 days of the original reading. All five cats had a spontaneous decrease in ammonia levels without any specific treatment for hyperammonaemia. Conclusions and relevance Pursuant to the findings of this retrospective study, transient hyperammonaemia may be noted after epileptic seizure in cats. Consequently, a differential diagnostic list in feline patients with hyperammonaemia could, depending on the context, include non-hepatic-related pathologies, such as epileptic seizures.

Publisher

SAGE Publications

Subject

Small Animals

Cited by 2 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Hyperammonaemia in cats;Companion Animal;2024-04-02

2. Management of status epilepticus in dogs;In Practice;2023-11

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