Effect of background region of interest and time-interval selection on glomerular filtration ratio estimation by percentage dose uptake of 99mTc-DTPA in comparison with 51Cr-EDTA clearance in healthy cats

Author:

Debruyn Katrien1,Vandermeulen Eva1,Saunders Jimmy H1,Dobbeleir André A1,Ham Hamphrey R2,Peremans Kathelijne1

Affiliation:

1. Department of Veterinary Medical Imaging and Small Animal Orthopaedics, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium

2. Department of Nuclear Medicine, University Hospital Gent, Ghent University, Ghent, Belgium

Abstract

Evaluation of glomerular function is a useful part of the diagnostic approach in animals suspected of having renal disease. Time-interval and background region of interest (bg ROI) selection are determining factors when calculating the glomerular filtration ratio (GFR) based on percentage uptake of 99mtechnetium-labelled diethylene triamine penta-acetic acid (99mTc-DTPA). Therefore, three different time intervals (60–120 s, 120–180 s, 60–180 s) and three different bg ROIs (C-shape, caudolateral, cranial + caudal) were investigated. In addition, global GFRs based on percentage dose uptake of 99mTc-DTPA for the different time-intervals and bg ROIs were compared with the global GFR based on 51chromium-ethylene diaminic tetra-acetic acid (51Cr-EDTA) plasma clearance in nine healthy European domestic shorthair cats. Paired Student’s t-tests and linear regression analysis were used to analyse the data. Different time intervals seemed to cause significant variation ( P <0.01) in absolute GFR values, regardless of the choice of bg ROI. Significant differences ( P <0.01) between bg ROIs were only observed in the 120–180s time interval between the C-shape and cranial + caudal bg ROI, and between the caudolateral and cranial + caudal bg ROI. The caudolateral bg ROI in the 60–180 s time interval showed the highest correlation coefficient (r = 0.882) between 99mTc-DTPA and 51Cr-EDTA, although a significant difference ( P <0.05) was present between both techniques.

Publisher

SAGE Publications

Subject

Small Animals

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