Mechanisms of action of currently available woman-controlled, vaginally administered, non-hormonal contraceptive products

Author:

Chappell B. Todd1,Griffin Brooke L.2,Howard Brandon3ORCID

Affiliation:

1. Adams Patterson Gynecology & Obstetrics, Memphis, TN, USA

2. College of Pharmacy, Downers Grove Campus (CPDG), Midwestern University, Downers Grove, IL, USA

3. Consultant, Evofem Biosciences, Inc., 12400 High Bluff Drive, Suite 600, San Diego, CA 92130, USA

Abstract

Woman-controlled, vaginally administered contraceptives offer women discreet, self-administered, and reversible options. This brief report summarizes the mechanisms of action (MOAs) of currently available, woman-controlled, vaginally administered, non-hormonal products, excluding those that need to be fitted by a healthcare provider. MOAs of three general types of contraceptives will be reviewed, including pH modulators, spermicides, and barrier methods. The recently approved vaginal pH modulator (lactic acid, citric acid, and potassium bitartrate) has a non-hormonal MOA, acting as a buffering agent in the presence of alkaline semen and resulting in sperm immobilization. In contrast, spermicides, such as nonoxynol-9, act by lysing sperm membranes, resulting in sperm death. Barrier methods, such as the diaphragm and female condom, prevent sperm from entering the uterus. In addition to their varying MOAs, each woman-controlled, vaginally administered method has different instructions for use, efficacy, side effects, and availability/insurance coverage, thus providing a range of characteristics to fit different needs and preferences.

Publisher

SAGE Publications

Reference29 articles.

1. Guttmacher Institute. Contraceptive use in the United States, https://www.guttmacher.org/fact-sheet/contraceptive-use-united-states (accessed 1 March 2022).

2. International survey to assess women's attitudes regarding choice of daily versus nondaily female hormonal contraception

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