Association of vitamin A with gestational diabetes and thyroid disorders in pregnancy and their influence on maternal, fetal, and neonatal outcomes

Author:

Qadeer Abdul1,Ishaq Muhammad Umer2,Safi Adnan3,Akbar Anum4ORCID,Asif Sana2,Komel Aqsa2,Kunwar Digbijay5ORCID,Bokhari Syed Mujtaba Azhar6

Affiliation:

1. Department of Cardiovascular Medicine, Shifa International Hospital, Islamabad, Pakistan

2. Department of Medicine, Nishtar Medical University, Multan, Pakistan

3. Department of Internal Medicine, Lahore General Hospital, Lahore, Pakistan

4. Department of Pediatrics, University of Nebraska Medical Center, Omaha, NE, USA

5. Department of Medicine, Bagahi Primary Healthcare Center, Parsa, Birgunj 44300, Nepal

6. Department of Medicine, King Edward Medical University, Lahore, Pakistan

Abstract

Gestational diabetes mellitus (GDM) and thyroid disorders during pregnancy pose significant health concerns, impacting a substantial number of mothers globally. Globally, about 14% of pregnant women develop GDM, while thyroid disorders impact approximately 2%–3%. Both conditions contribute to adverse outcomes, including gestational hypertension, excessive fetal growth, and heightened perinatal morbidity. The central focus of this literature review is to examine the relationship between vitamin A, a crucial fat-soluble micronutrient in fetal development, and the occurrence of GDM and thyroid disorders during pregnancy. The primary research question investigates the association between vitamin A, GDM, and thyroid disorders, analyzing their combined impact on maternal, fetal, and neonatal outcomes. The review underscores the potential of vitamin A to modulate the risk and outcomes of GDM and thyroid disorders during gestation, emphasizing its role in GDM development and resolution and its influence on thyroid function in pregnancy.

Publisher

SAGE Publications

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