Non-Hodgkin lymphoma–associated AA amyloidosis

Abstract

Amyloidosis is a rare complication of non-Hodgkin lymphoma, almost exclusively of AL-type, AA-type amyloidosis secondary to non-Hodgkin lymphoma is extremely rare. We report a case of a 55-year-old woman diagnosed with follicular lymphoma that developed nephrotic proteinuria; further investigation confirmed the diagnosis of AA-type amyloidosis, and other long-term inflammatory disorders were excluded. Despite initiation of combined chemotherapy, there was no hematological response and kidney function and clinical condition continued to deteriorate. This case describes an unexpected association, AA-type amyloidosis secondary to non-Hodgkin lymphoma, a condition with poor renal prognosis where treating the underlying disease is paramount.