Fibroblast growth factor 23–secreting pancreaticobiliary malignancy

Author:

Barta Valerie1,Lalkiya Neel2,Phan Huy2,Miller Ilene3,Sachdeva Mala3

Affiliation:

1. Lenox Hill Hospital, Northwell Health, New York, NY, USA

2. Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY, USA

3. Division of Kidney Diseases and Hypertension, Northwell Health, Great Neck, NY, USA

Abstract

Malignancy-related tumor-induced osteomalacia is a rare but important entity. We report the first case of oncogenic renal phosphate wasting in the setting of a pancreaticobiliary malignancy. Our patient presented with refractory hypophosphatemia. Workup revealed high fibroblast growth factor 23 levels as well as a new pancreaticobiliary mass. All other causes of hypophosphatemia were ruled out. With tumor-induced osteomalacia, an accurate diagnosis and location of the offending tumor is essential for appropriate management and treatment.

Publisher

SAGE Publications

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