High-flux hemodialysis versus glucarpidase for methotrexate-associated acute kidney injury: What’s best?-Reference-Cited by-同舟云学术

High-flux hemodialysis versus glucarpidase for methotrexate-associated acute kidney injury: What’s best?

Published:2019-02 Issue:1 Volume:3 Page:11-18
ISSN:2399-3693
Container-title:Journal of Onco-Nephrology
language:en
Short-container-title:Journal of Onco-Nephrology

Author:

Kitchlu Abhijat¹,Shirali Anushree C²^ORCID

Affiliation:

1. Division of Nephrology, Department of Medicine, University of Toronto, Toronto, ON, Canada

2. Section of Nephrology, Yale School of Medicine, Yale University, New Haven, CT, USA

Abstract

Kidney-related adverse drug effects from chemotherapeutic agents can cause acute kidney injury that may influence cancer treatment and patient outcomes. Many current chemotherapy drugs are associated with acute kidney injury, including methotrexate which causes dose-dependent tubular injury. In this review, we will focus on the manifestations of kidney disease secondary to methotrexate and discuss management strategies. In particular, we will review the use of high-flux hemodialysis versus glucarpidase for reducing toxic serum levels of methotrexate.

Publisher

SAGE Publications

Link

http://journals.sagepub.com/doi/pdf/10.1177/2399369319827305

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