Management of Hepatitis C virus Genotype 2 or 3 Infection: Treatment Optimization on the Basis of Virological Response

Author:

Zeuzem Stefan1,Rizzetto Mario2,Ferenci Peter3,Shiffman Mitchell L4

Affiliation:

1. JW Goethe University Hospital, Frankfurt, Germany

2. Division of Gastro-Hepatology, Ospedale San Giovanni Battista (Molinette), Torino, Italy

3. Department of Internal Medicine III, Gastroenterology and Hepatology, University of Vienna, Vienna, Austria

4. Hepatology Section, Virginia Commonwealth University Medical Center, Richmond, VA, USA

Abstract

Current guidelines recommend a full 24-week regimen for all patients undergoing treatment for genotype 2 or 3 hepatitis C virus (HCV) infection. Recent data from two large randomized studies, one with pegylated interferon-α2a plus ribavirin (RBV) and one with pegylated interferon-α2b plus RBV assessed treatment duration and on-treatment predictors, such as rapid virological response (RVR; HCV RNA <50 IU/ml at week 4) or sustained virological response rates. Overall, these studies have shown that abbreviated regimens are generally less effective than standard 24-week regimens in genotype 2 or 3 patients because of a higher rate of relapse. However, abbreviated treatment might be offered to selected patients with an RVR provided that they have a low baseline viral load and minimal hepatic fibrosis.

Publisher

SAGE Publications

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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