Affiliation:
1. Hopital d'Instruction des Armées Desgenettes, Lyon
2. Hopital Laveran, Marseille
3. Laboratoire Chauvin, Montpellier - France
Abstract
Purpose To evaluate the analgesic action of combined indomethacin 0.1% / gentamicin eyedrops in traumatic corneal abrasion. Methods We evaluated 123 patients presenting traumatic corneal abrasion in a multicentre, randomised, double-masked study comparing two parallel treatment groups: indomethacin / gentamicin (group 1) or gentamicin alone (group 2). Study treatments were administered four times daily for 5–6 days. Pain (visual analogue scale), associated symptoms and safety were assessed. Results Starting from a comparable level, pain was reduced by 30% in group 1 and 15% in group 2, one hour after the first instillation, and by 59% and 42% respectively after the second. The global difference in pain relief from day 0 to day 4/5 was significantly better in group 1 (p = 0.015). Associated ophthalmic symptoms showed a greater decrease in group 1 after the first instillation (p = 0.007). Both treatments were well tolerated. Conclusions Combined indomethacin/gentamicin eyedrops were effective and well tolerated in reducing the pain and discomfort associated with traumatic corneal abrasion.
Subject
Ophthalmology,General Medicine
Cited by
19 articles.
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