Wide-field individual retinal layer thickness in healthy eyes

Author:

Singh Sumit Randhir1,Invernizzi Alessandro2ORCID,Rasheed Mohammed Abdul1,Cagini Carlo3ORCID,Goud Abhilash1,Gujar Ramkailash3,Pandey Priti1,Vupparaboina Kiran Kumar1,Cozzi Mariano2,Lupidi Marco3,Chhablani Jay14ORCID

Affiliation:

1. Smt. Kanuri Santhamma Centre for Vitreo-Retinal Diseases, L V Prasad Eye Institute, Hyderabad, India

2. Department of Biomedical and Clinical Science “Luigi Sacco,” Eye Clinic, University of Milan, Milan, Italy

3. Department of Biochemical and Surgical Sciences, Section of Ophthalmology, University of Perugia, Perugia, Italy

4. UPMC Eye Center, University of Pittsburgh, Pittsburgh, PA, USA

Abstract

Purpose To report the individual retinal layer thickness in healthy subjects using wide-field optical coherence tomography. Methods This was a prospective, cross-sectional study involving healthy subjects. A custom-designed semiautomated segmentation algorithm was used to split the retinal layers in seven bands, and individual retinal layer thicknesses were measured in horizontal (nasal, macular, and temporal segments) and vertical meridians (superior, macular, and inferior segments). The variation in retinal thickness was analyzed in different segments at an interval of 1 mm from reference points. Regression analysis was performed to identify the factors affecting retinal thickness. Results Twenty eyes of 20 healthy subjects with mean age of 28.9 ± 6.3 years were analyzed. Overall, nasal and superior segments (mean ± standard deviation: 279.6 ± 17.0 and 234.4 ± 19.2 µm) had maximum and minimum retinal thicknesses, respectively. A total of seven bands were delineated in each optical coherence tomography b scan in each segment. Retinal nerve fiber layer was thickest immediately nasal to optic disk margin in horizontal scan (72.4 ± 32.4 µm) and near the vascular arcades in vertical meridian. Outer plexiform layer, external limiting membrane–ellipsoid zone and interdigitation zone–retinal pigment epithelium–Bruch’s complex showed significant variation in both horizontal and vertical meridians (all p values <0.05). Macular segment in both meridians showed the highest coefficient of variation. Age was the only significant factor affecting retinal thickness in multiple regression analysis (p = 0.001). Conclusions Wide-field optical coherence tomography shows significant regional variation in overall and individual retinal layer thicknesses in macular and peripheral areas in healthy eyes with the highest variation in macular segment.

Publisher

SAGE Publications

Subject

Ophthalmology,General Medicine

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