A case of Vogt-Koyanagi-Harada-like uveitis secondary to dabrafenib/trametinib therapy for advanced melanoma-Reference-Cited by-同舟云学术

A case of Vogt-Koyanagi-Harada-like uveitis secondary to dabrafenib/trametinib therapy for advanced melanoma

Published:2020-10-01 Issue:1 Volume:32 Page:NP109-NP113
ISSN:1120-6721
Container-title:European Journal of Ophthalmology
language:en
Short-container-title:European Journal of Ophthalmology

Author:

Brambati Maria¹,Giuffrè Chiara¹,Marchese Alessandro¹^ORCID,Bandello Francesco¹^ORCID,Modorati Giulio Maria¹,Miserocchi Elisabetta¹^ORCID

Affiliation:

1. Department of Ophthalmology, San Raffaele Scientific Institute, University Vita-Salute, Milan, Italy

Abstract

We report a case of ocular drug toxicity consistent with bilateral Vogt-Koyanagi-Harada (VKH) like disease in a patient with cutaneous melanoma treated with Dabrafenib/Trametinib therapy. A 53-year-old man with a history of metastatic cutaneous melanoma, treated with Dabrafenib/Trametinib, developed a severe acute panuveitis with granulomatous anterior uveitis and multiple serous retinal detachments. The ocular inflammatory reaction was classified as a bilateral Vogt-Koyanagi-Harada disease. Intraocular inflammation resolved after discontinuation of chemotherapeutic agents and aggressive topical and systemic corticosteroid therapy. The present case outlines the importance of recognizing VKH-like syndrome as a possible consequence of therapy with dabrafenib and trametinib.

Publisher

SAGE Publications

Subject

Ophthalmology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1120672120962044

Reference10 articles.

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