Cationic nanoemulsion vs. 0.15% sodium hyaluronate artificial tears in the healing process following modern surface keratorefractive surgery

Author:

Jaworski Damian12ORCID,Cieślińska-Rypolc Agata12,Jadczyk-Sorek Katarzyna34ORCID,Jaworowska-Cieślińska Iwona2,Bubała-Stachowicz Beata4,Mrukwa-Kominek Ewa34,Kałużny Bartłomiej J12ORCID

Affiliation:

1. Division of Ophthalmology and Optometry, Department of Ophthalmology, Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland

2. Oftalmika Eye Hospital, Bydgoszcz, Poland

3. Department of Ophthalmology, Faculty of Medical Science in Katowice, Medical University of Silesia, Katowice, Poland

4. Department of Ophthalmology, Professor K. Gibiński University Clinical Center, Medical University of Silesia, Katowice, Poland

Abstract

Purpose The aim of this study was to investigate the influence of artificial tears containing either cationic nanoemulsion (CCN) or sodium hyaluronate artificial tears (SH) on early postoperative healing after modern surface refractive surgery. Materials and Methods In this multicenter, prospective, double-masked, parallel-group (1:1), comparative study, 129 patients (n = 255 eyes) were randomized to receive CCN (n = 128) or SH (n = 127) as an adjuvant treatment after either transepithelial photorefractive keratectomy (transPRK) or Epi-Bowman keratectomy (EBK). The patients’ perspectives were gathered using the Ocular Surface Disease Index (OSDI) questionnaire, and uncorrected (UCVA), and corrected (BCVA) visual acuity were assessed before and one week and one month after the procedure. In addition, corneal epithelization and subjective assessment of visual blur and eye irritation on drop instillation were assessed at one week postoperatively. Results No statistically significant differences were found between two groups in age, spherical equivalent refractive error, UCVA, BCVA or OSDI scores before the procedure. There was also no difference between groups in UCVA one week and one month after the procedure. However, statistically significantly lower OSDI scores were found one week and one month after the procedure in the CCN group. Moreover, blurred vision after use of the eye drops was observed less frequently in the CCN group than in the SH group. Conclusions The CCN and SH groups had similar postoperative UCVA. However the significantly lower OSDI scores and less frequently blurred vision after application of the eye drops in the CCN group suggest better subjective outcomes in this group.

Funder

Santen

Publisher

SAGE Publications

Subject

Ophthalmology,General Medicine

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