Doxycycline sclerotherapy in patients with periorbital lymphatic malformation: A case series and literature review

Author:

Lai Kenneth K.H.1ORCID,Kwok Yuen Ting2,Lam Stacey C.2,Lam Matthew C.W.2ORCID,Yuen Hunter K.L.23

Affiliation:

1. Department of Ophthalmology, Tung Wah Eastern Hospital, Hong Kong Special Administrative Region

2. Hong Kong Eye Hospital, Hong Kong Special Administrative Region

3. Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong Special Administrative Region

Abstract

Purpose To describe and report the outcomes of doxycycline sclerotherapy in patients with periorbital lymphatic malformations(LMs). Basic procedures A retrospective review of consecutive patients diagnosed with periorbital LMs and who received doxycycline sclerotherapy at Hong Kong Eye Hospital and Queen Elizabeth Hospital, Hong Kong between January 2016 and June 2022. Doxycycline was prepared with a concentration of 100 mg diluted in 10 mL water for injection. A 23-gauge needle aiming at the center of the macrocyst was used to aspirate fluid from the lesion; this was then followed by an intralesional injection of 0.5 to 2 ml of doxycycline depending on the size of the cavity. Main findings A total of eight patients(six females) were included in this study. All of them received doxycycline sclerotherapy for periorbital LMs(five extraconal, three intraconal). The median age for receiving sclerotherapy was 29 years old. Seven patients had macrocystic LMs, and one had mixed macro- and microcystic LM. Two of the LMs had venous components radiologically. The average number of sclerotherapy treatment in one patient was 1.4 ± 0.7times. Seven of the eight patients had excellent response radiologically or clinically. One patient showed a satisfactory response after three cycles of sclerotherapy. No recurrence was experienced at median follow-up of 14 months. None of the patients experienced visual threatening or systemic complication. Principle conclusions Our preliminary experience with doxycycline sclerotherapy has shown encouraging results for the treatment of macrocystic or mixed-type periorbital LMs, with a favourable safety profile. Further clinical trials with longer follow-ups are warranted on this topic.

Publisher

SAGE Publications

Subject

Ophthalmology,General Medicine

Reference34 articles.

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