Cardiac Output and Propofol Concentrations in Prone Surgical Patients-Reference-Cited by-同舟云学术

Cardiac Output and Propofol Concentrations in Prone Surgical Patients

Published:2011-09 Issue:5 Volume:39 Page:868-874
ISSN:0310-057X
Container-title:Anaesthesia and Intensive Care
language:en
Short-container-title:Anaesth Intensive Care

Author:

Leslie K.¹²,Wu C. Y.-X.¹³,Bjorksten A. R.¹³,Williams D. L.¹⁴,Ludbrook G.¹⁵,Williamson E.¹⁶

Affiliation:

1. Department of Anaesthesia and Pain Management, Royal Melbourne Hospital, Departments of Pharmacology and Medicine, University of Melbourne, Melbourne, Victoria and Department of Anaesthesia, University of Adelaide, Adelaide, South Australia, Australia

2. Department of Anaesthesia and Pain Management and Honorary Professorial Fellow, Department of Pharmacology, University of Melbourne.

3. Department of Anaesthesia and Pain Management.

4. Department of Anaesthesia and Pain Management, Royal Melbourne Hospital and Clinical Associate Professor, Department of Medicine, University of Melbourne.

5. Department of Anaesthesia, University of Adelaide.

6. Department of Epidemiology and Preventive Medicine, Monash Univeristy and Molecular, Environmental, Genetic and Analytic Epidemiology, School of Population Health, University of Melbourne.

Abstract

The aim of this study was to compare cardiac output and plasma propofol concentrations in the supine and prone positions in healthy adult patients presenting for lumbar spine surgery. Patients received propofol and remifentanil via effect-site steered target-controlled infusions. Cardiac output and plasma propofol concentration were compared during 20 minutes in the supine position and 20 minutes after positioning on a Wilson frame. Cardiac output did not change significantly over 20 minutes in either position (P=0.37) and was similar at 20 minutes in the supine (6.1 [1.6] l/minute) and prone positions (6.1 [1.9] l/minute) (P=0.87). Propofol concentrations were similar in the supine and prone positions at 20 minutes (2.55 [0.89] and 2.53 [0.90] μg/ml; P=0.93). We conclude that prone positioning on the Wilson frame does not affect cardiac output or plasma propofol concentration.

Publisher

SAGE Publications

Subject

Anesthesiology and Pain Medicine,Critical Care and Intensive Care Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/0310057X1103900511

Reference22 articles.

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4. Influence of the prone position on propofol pharmacokinetics

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