Initial Clinical Experiences with Althesin (CT 1341) in Malaysian Patients

Abstract

The history of steroidal intravenous anaesthesia is traced. Althesin was used as an induction agent in 60 elective minor gynaecological procedures requiring general anaesthesia, followed by nitrous oxide/oxygen maintenance anaesthesia. Clinical assessment showed predominantly a transient hypotension (10–20 mm Hg fall in systolic blood pressure), a rise in pulse and respiratory rates. Recovery was smooth, rapid and pleasant. As an induction agent Althesin (CT 1341) has effects similar to the well-known and established side-effects of the ultra-short-acting barbiturates. The obvious advantage would be for patients in whom barbiturates are contraindicated. The clear-headed, pleasant recovery should enhance its value for outpatient minor procedures requiring general anaesthesia.