Fracture healing and bone repair: an update

Author:

Tosounidis Theodoros1,Kontakis George1,Nikolaou Vassilis2,Papathanassopoulos Argiris2,Giannoudis Peter V3

Affiliation:

1. Department of Orthopaedics and Traumatology, University of Crete, Greece

2. Academic Department of Trauma and Orthopaedics, University of Leeds, UK

3. Academic Department of Trauma and Orthopaedics, University of Leeds, UK,

Abstract

Bone healing represents a physiological process of repair and restoration of function. Recent advances in a variety of medical disciplines have enabled scientists and clinicians to characterise this phenomenon at the molecular level. A number of molecular mediators and cells interact utilising different pathways. Despite the involvement of many local and systemic factors failure of the naturally occurring mechanisms can occur leading to either delayed union or non-union. This review article is focused on the recent understanding of the mechanisms governing the bone repair process.

Publisher

SAGE Publications

Subject

Critical Care and Intensive Care Medicine,Emergency Medicine,Surgery

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